To this end, congenic naive (CD45.1+CD44loCD62Lhi) P14 CD8+ T cells recognizing the lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP) epitope H-2DbGP33–41 and congenic naive (CD45.1+CD44loCD62Lhi) SMARTA (SM) CD4+ T cells recognizing the LCMV GP epitope I-AbGP66–77 were adoptively transferred into C57BL/6 recipients (CD45.2+), which were then infected with LCMV Armstrong to establish acute viral infection and resultant virus-specific P14 TMEM and SM TMEM cells. This evidence concerns the gene CD4 and viral infectious disease.