CD8A and neoplasm: Moreover, in-depth TCR repertoire analysis indicated that p15E-specific CD8+ T cells from the NDV-GP group exhibited TCR clones of greater breadth and diversity than their counterparts from PBS or NDV-WT groups (Fig. 6g), further corroborating the notion that OV-BYTE therapy targeting virus-specific epitopes virtually led to epitope spreading of tumor-specific antigens and, as a result, enhanced TTST cell responses.