AKT1 and cancer: Aside from transplanted tumor models, NDV-GP administration also largely improved the survival rates of mice with LCMV memory and Notch intracellular domain (NICD)- and AKT-induced autochthonous intrahepatic cholangiocarcinoma35 (Fig. 2n,o), suggesting the potential efficacy of OV-BYTE therapy in different cancer types.