MIX23 and pancreatic adenocarcinoma: Through analyzing RNA-seq data from TCGA and Illumina human methylation 450 methylation data using two probes (cg16509192 and cg13010990), we found that CCDC58 expression was negatively correlated with its promoter methylation in HNSC, KICH, and LIHC, positively correlated in PAAD and UCEC (Fig. 4D).