ZIP13G64D protein is readily degraded via the valosin-containing protein-linked ubiquitin–proteasome pathway, which is attributed as the main cause of EDSSPD38; i.e., loss of functional ZIP13 protein is the molecular mechanism underlying the pathogenesis of EDSSPD3. Here, SLC39A13 is linked to Ehlers-Danlos syndrome, spondylocheirodysplastic type.