Besides, dysregulation in post-transcriptional modifications, like ubiquitination enzymes (HUWE1, CUL4A, TRIM25, etc.)and deubiquitination enzymes (USP7, USP10, USP24, etc.)in these PTC tumor samples (Supplementary Fig. S6d) may also lead to the low consistency. The gene discussed is CUL4A; the disease is neoplasm.