Proteins like tenascin (TNC), fibronectin 1 (FN1), dipeptidyl peptidase 4 (DPP4), and phosphoproteins of major vault protein (MVP) and FN1 showed remarkable upregulation in the PTC tumor tissues, while proteins thyroid peroxidase (TPO), desmin (DES) and fatty acid binding protein 4 (FABP4), and phosphoproteins of thyroglobulin (Tg), DES, hemoglobin subunit delta (HBD) and hemoglobin subunit beta (HBB) were downregulated in the PTC tumors (Fig. 2b). This evidence concerns the gene HBD and neoplasm.