Proteins like tenascin (TNC), fibronectin 1 (FN1), dipeptidyl peptidase 4 (DPP4), and phosphoproteins of major vault protein (MVP) and FN1 showed remarkable upregulation in the PTC tumor tissues, while proteins thyroid peroxidase (TPO), desmin (DES) and fatty acid binding protein 4 (FABP4), and phosphoproteins of thyroglobulin (Tg), DES, hemoglobin subunit delta (HBD) and hemoglobin subunit beta (HBB) were downregulated in the PTC tumors (Fig. 2b). The gene discussed is TPO; the disease is neoplasm.