KLB and Insulin resistance: Notably, KD-induced improvement of overweight (30.72 ± 1.49 vs 35.68 ± 3.74 g; P < 0.05), excessive body fat (4.52 ± 0.26 vs 8.06 ± 1.36 g; P < 0.001), hyperglycemia (7.82 ± 0.73 vs 9.90 ± 1.32 mmol/L; P < 0.05), and insulin resistance were diminished after KLB knockdown in mouse livers (Fig. 4B, C and E, F).