GBA1 and Parkinson disease: To dissect the impact of GBA-N370S iPSC-DaNs on the physiology of corticostriatal output neurons, we established the striatal microcircuit using iPSC-CNs and -MSNs from healthy controls connected with iPSC-DaNs from either healthy controls or PD patients carrying the GBA-N370S mutation (Fig. 5A).