CD4 and neoplasm: When examining levels of tumor-infiltrating lymphocytes (TILs) in Cd4CreNrp1+/+, Nrp1Flox/+ and Nrp1Flox/Flox mice, we noticed a significant increase in the numbers of CD8+ T cells within tumors in Cd4CreNrp1Flox/Flox mice, but not of CD4+ T cells (Fig. 2d, Supplementary Fig. 2I).