Conversely, research by Vignali and colleagues has shown that NRP1 plays a key role in Treg survival and suppressive capabilities through ligation with Sema4A62,65, and so affecting NRP1 on both T cell subsets likely allows the immune system to better control tumor growth, than removal of NRP1 on CD8+ T cells alone can. The gene discussed is NRP1; the disease is neoplasm.