S100A4 and breast cancer: Our results suggest that, on one side, ANXA9 could regulate AKT/mTOR/STAT3 to regulate p53 signal pathway, participating BC metastasis and on the other side, ANXA9 facilitates the transfer of S100A4 out of BC cells, recruiting several cytokines to help cancer metastasis via angiogenesis (Fig. 8F).