In the S100 protein family, S100A4 participates in multiple phenotypic changes that affect tumor cells, including promoting the proliferation of acute leukemia cells [32], increasing the metastatic ability of ovarian cancer cells [33], and promoting the degradation and remodeling of extracellular matrix in the microenvironment of breast tumors [34]. The gene discussed is S100A4; the disease is breast neoplasm.