Activation of other NRs such as vitamin D receptor (VDR) and liver X receptor (LXR) is also shown to be protective in various disease conditions such as cardiovascular disease, diabetes, and neurodegenerative diseases by modulating ER stress (Riek et al, 2012; Yao et al, 2015; Gavini et al, 2018; Gui et al, 2018; Zhou et al, 2020). This evidence concerns the gene VDR and diabetes mellitus.