Two recent large case control studies CARRIERS in the USA3 and BRIDGES mainly in Europe4 identified six additional genes with actionable increased risks of breast cancer with ORs of around twofold to threefold (RAD51C, RAD51D, BARD1, ATM, CHEK2) and one at fourfold to fivefold (PALB2). The gene discussed is CHEK2; the disease is breast carcinoma.