Mepolizumab treatment reduced levels of the ECM proteins tenascin, lumican and procollagen III and airway eosinophils expressing TGF-β1 in the bronchial biopsies of patients with mild atopic asthma, as well as TGF-β1 levels in bronchoalveolar lavage [151]. Here, TGFB1 is linked to atopic asthma.