BDNF and Huntington disease: Although reduced BDNF supply from cortical neurons has been implicated as contributing to striatal degeneration in HD (Baydyuk and Xu, 2014; Gauthier et al., 2004; Su et al., 2014; Yu et al., 2018; Zuccato and Cattaneo, 2007, 2009), our current study has revealed that reduced BDNF is also likely responsible for synaptic deficits in BACHD cortical neurons.