The researchers showed that FOXC2 mediates the G2/M transition in BRCA stem cell lines through upregulation of cell cycle protein-dependent kinase 1 (cyclin-dependent kinase 1) expression.[19] In our study, FOXC2 expression was lower in BRCA tissues than in normal tissues, but its expression was not significantly correlated with tumor stage. The gene discussed is CDK1; the disease is neoplasm.