FOXO3 and neoplasm: In recent years, the TME has been increasingly researched and has become an important therapeutic target.[43] TME can promote tumor development, growth, and suppress immune function through a variety of complex intercellular signaling pathways.[58] In our study, the expression levels of FOXA1, FOXC2, FOXO3, FOXM1, FOXP1, and FOXQ1 were significantly associated with the levels of immune cells.