NOTCH1 and cervical cancer: These types of mutations may have a higher tendency to occur in tumor suppressor genes, disrupting their growth-inhibitory functions.[44] Additionally, studies have shown that neoantigens derived from indel mutations were enriched for mutant-specific binding, as compared to neoantigens derived from nonsynonymous single nucleotide variant mutations.[45] Furthermore, we found that the elderly group had a higher enrichment of NOTCH1 and TP53 mutations, both of which are considered important tumor suppressor genes in cervical cancer.