ZFP42 encodes the Rex1 protein, which activates the MEK/ERK pathway to promote tumorigenesis in prostate cancer and promotes EMT-induced cell metastasis by activating the JAK2/STAT3-signaling pathway in cervical cancer.[31,32] Conversely, the most significantly downregulated gene in the young group was PNMA5, which encodes a member of the paraneoplastic Ma antigen protein family (Fig. 3C). Here, JAK2 is linked to Familial prostate cancer.