TNF and obesity due to melanocortin 4 receptor deficiency: These molecules can play a role in obesity-related inflammation and NAFLD.[4] In the case of over-expansion of adipose tissue, macrophage infiltration occurs and pro-inflammatory cytokines including interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) and chemerin levels increase.[5] Chemerin is secreted mainly from adipose tissue, the liver, and the lungs.