Recent studies have shown that M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting toll-like receptor 3 and COL10A1 to alleviate osteoarthritis.[39] Besides, studies have found that Cinobufagin upregulated MME and inactivated FAK/STAT3 signaling to regulate macrophage reprogramming and inhibit triple-negative breast cancer. Here, TLR3 is linked to osteoarthritis.