Our work represents a solid alternative to existing therapeutics.[40] Quercetin-induced suppression of transient receptor potential vanilloid subtype 1 leads to a delay in osteoarthritis progression by shifting the macrophage polarization from M1 to M2 subtypes via modulation of the P2X7/NLRP3 pathway.[41] By regulating Cx43 expression, our work provides an alternative method to osteoarthritis.[40]. Here, GJA1 is linked to osteoarthritis.