These fragments are predominantly excreted in the urine after crossing the glomerular filtration barrier.[134] Several clinical studies have ascertained the capability of hs-cTns immunoassays to detect cTnI molecules in the urine of patients with AMI.[135–141] Conversely, Mb, owing to its small molecular weight, is promptly released from the injured myocardium and rapidly excreted from the kidneys within 24 hours.[44] Urine serves as an ideal noninvasive sample that can be easily collected in large volumes,[142] offering unprecedented possibilities for the diagnosis of MI. Here, CTNS is linked to myocardial infarction.