MB and Abnormal renal physiology: Moreover, Mb is regarded as the most sensitive indicator for early prediction of AMI.[46] Nevertheless, its specificity is limited owing to the influence of skeletal muscle disease and renal dysfunction on its concentration.[47] Hence, the use of Mb alone in diagnosing AMI is insufficient, and it is typically combined with other indicators, such as cTns, CK-MB, ECG, and clinical symptoms.