GAN and giant axonal neuropathy: The CMT-associated mutations include biallelic mutations in the GAN gene, which leads to loss of function of Gigaxonin a substrate adaptor of Cul3-E3 ubiquitin ligases and causes giant axonal neuropathy (GAN), a progressive childhood neurodegenerative disease that presents as a prominent sensorimotor neuropathy and affects both the peripheral nervous system and central nervous system (7).