Mutations in RAB18, RAB3GAP1, RAB3GAP2, and TBC1D20 have caused Warburg micro syndrome, a rare autosomal recessive multisystem disorder [40], suggesting that RAB3GAP1, RAB3GAP2, and TBC1D20 might play roles in PRRSV-2 replication. This evidence concerns the gene RAB18 and Warburg micro syndrome.