In mice, Tnc, Gpc6, Cryab, and Gbp2 were reported to promote neuron regeneration and synapse formation following stroke-induced injury (Chen et al., 2021; Saglam et al., 2021; Chen et al., 2010; Ugalde et al., 2020); Vmp1, Chi3l1, Spp1, Vim, and Itgb1 associated with autophagy, proliferation, and regeneration (Zhao et al., 2017; Nishimura et al., 2021; Sojan et al., 2022; Kong et al., 2018); and Cyr61, CD63, Actn4, Ell2, and Spocd1 demonstrated to promote proliferation (Kong et al., 2018; Thines et al., 2022; Chen et al., 2022; Alexander et al., 2017; Liu et al., 2018). The gene discussed is SPP1; the disease is Stroke.