Of note, in dual-loss subtype, angiogenesis and fatty acid oxidation (FAO)/AMP-activated protein kinase (AMPK) pathways were activated while cell cycle and fatty acid synthesis (FAS)/pentose phosphate pathways were reduced, suggesting dual-loss ccRCC might harbor a reprogrammed fatty acid metabolism (Supplementary Fig. 9B). The gene discussed is FAS; the disease is nonpapillary renal cell carcinoma.