We discovered an increase of CD57+ CD8+ T cells expressing immune checkpoints, PD-1+ TIGIT+ LAG3+ TIM-3+ in ICI-ILDs, which supports our previous findings of increased proportions of CD8+ T cells positive for both PD-1 and TIM-3 or TIGIT in ICI-ILD (Suzuki et al., 2020). Here, LAG3 is linked to interstitial lung disease.