PRKN and Parkinson disease: In addition, Miro GTPases have been implicated in Parkinson’s disease—and possibly other neuropathological conditions—based on their interactions with the Parkinson protein Parkin, which is an E3 ubiquitin ligase, and the PTEN-induced kinase (PINK1), which is a Ser/Thr protein kinase [7,8,9,10].