The reduction in M- and PMN-MDSC numbers in the early stage goes at the same pace as IL-6 expression, which is reported to be decreased in the early AD phases with respect to healthy mice, whereas MDSCs increase in the late stage correlates with enhanced expression of pro-inflammatory cytokines, i.e., TNF-α and IL-6 [31]. The gene discussed is TNF; the disease is Alzheimer disease.