Quercetin is a polyphenolic flavonoid exhibiting anticancerous features that exert its therapeutic mechanism in hepatocellular carcinoma through dysregulation of several signaling mechanisms, including PI3K/AKT, NF-κB, P53, Wnt/β-catenin, MAPK, JAK/STAT, and the Hedgehog pathway. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.