REN and glioblastoma: Interestingly, high REN expression was significantly associated with poorer OS in glioblastoma cases after multivariate analysis (HR = 2.25 (1.05–4.8), p = 0.036), despite a non-significant trend after univariate Cox regression (HR = 1.53 (0.89–2.65), p = 0.13) (Figure 2D, Table S2).