Thus, we saw two distinct abnormal proangiogenic signatures in the tumor and the paired adjacent normal peritumoral mucosa—we recognize the leading role of the overexpressed HIF-1α in the tumor samples, whereas there is an evident shift towards HIF-2α upregulation and lowering of the expression of the first isoform in the peritumor mucosa. The gene discussed is HIF1A; the disease is neoplasm.