Brain and muscle Arnt-like protein 1 (BMAL1), a protein involved in circadian rhythm regulation, cooperates with EZH22 to repress the expression of glycerol-3-phosphate acyltransferase mitochondrial (GPAM) and subsequently reduce LPA levels, providing the potential to open a new therapeutic avenue for hepatocellular carcinoma treatment [96]. Here, BMAL1 is linked to hepatocellular carcinoma.