Keeping up with the role of LPA and its receptors in immune regulation, LPA controls the expression of a wide range of cytokines, including tumour necrosis factor α (TNFα) and interleukin-1β (IL-1β), IL-6, IL-8 and chemokine (C-X-C motif) ligand 1 (CXCL1) through EGFR transactivation to establish the formation of a pro-tumourigenic inflammatory network in ovarian cancer [115]. The gene discussed is EGFR; the disease is ovarian cancer.