Moreover, VDAC1 depletion not only leads to the reprogramming of cancer cell metabolism, but it also alters several epigenetic-related enzymes and factors such as the acetylation-related enzymes SIRT6, HDAC2, and SIRT1 and changes the acetylation and methylation profiles of histone 3 and histone 4 [18], pointing to an interplay between metabolism and epigenetics. Here, VDAC1 is linked to cancer.