Our finding that the expression levels of KRT-14, SOX2, CD44, and ALDH1a decreased upon si-m/hVDAC1-B BC treatment suggests that the metabolic reprogramming of cancer cells via VDAC1 depletion reduces CSC markers, suggesting the inhibition of their proliferation and/or induction of differentiation. The gene discussed is VDAC1; the disease is breast cancer.