To evaluate the dose-dependent effect of Sec C, different concentrations of 0, 0.075, 0.1500, 0.3125, 0.625, 1.25, 2.5, 5.0, and 10.0 μmol/L Sec C were separately added to six types of colorectal tumor cells (HCT8, HT29, HCT116, RKO, HCT15, and CW2 cells) for 48 h. Here, SIAE is linked to colorectal neoplasm.