Studies have confirmed that S100A8 is upregulated in various tumor cells, including colorectal cancer, anaplastic thyroid carcinoma, breast cancer, lung cancer, and acute myeloid leukemia, and is involved in regulating cell proliferation, metastasis, invasion, drug resistance, angiogenesis, and immunosuppression [30,31,32,33,34,35,36,37]. The gene discussed is S100A8; the disease is neoplasm.