According to the COSMIC (Catalogue of Somatic Mutations in Cancer, URL https://cancer.sanger.ac.uk/cosmic accessed on 01 August 2023), STAG1 (5%), NIPBL (4.9%), STAG2 (3.4%), and PDS5B (3.4%) are the most frequently mutated in cancer [26]. The gene discussed is STAG1; the disease is cancer.