The overexpression of the glia maturation factor [GMF], a pro-inflammatory protein that has been demonstrated to orchestrate the immune cell–neuron–glia crosstalk in vitro and in animal models of PD [63], was also observed in the substantia nigra and corpus striatum of human PD brains, in close contact with areas of neuronal degeneration [64]. The gene discussed is GMFB; the disease is Parkinson disease.