Moreover, through autophagy targeting of the ZIKV NS5 protein, HDAC6 has emerged as a key anti-ZIKV factor that can control NS5-mediated functions in cells, such as aberrant alteration of the tubulin cytoskeleton and inhibition of autophagic p62 flux; thus, HDAC6 is a potential protective factor against cell toxicity and associated ZIKV infection pathogenesis. This evidence concerns the gene RAF1 and Zika virus infectious disease.