RAF1 and viral infectious disease: Therefore, the ZIKV NS5 protein affects cell structures and events that are key for cell permissivity to viral infection and survival, such as tubulin cytoskeleton dynamics or p62-associated autophagy flux [97,98,99,100,101,102,103], which are functions regulated by the antiviral factor HDAC6 [91,94,98,99,100,101,104,105,106,107,108], presumably to protect itself from fading and accomplishing its viral functions.