The LGMD2 group displays sarcoglycanopathies, in which mutations occur in genes encoding most of the proteins of the sarcoglycan complex, SGCA, B, G, and D; LGMD2A (now LGMDR1) is caused by the loss of a functional Calpain 3 protein, and LGMD2B (now LGMDR2) is consequent to mutations in the DYSF gene. This evidence concerns the gene CAPN3 and autosomal recessive limb-girdle muscular dystrophy type 2A.