Interferon alpha (IFN-α), interferon beta (IFN-β), which are included in the interferons type I family, interferon-gamma (IFN-γ), representing interferon type II, and the recent family of interferon type III (IFN-λ) [97] consist of cytokines produced as part of the innate immune response, and their immunomodulatory actions have been used in the treatment of several malignancies, including CTCL [258]. Here, IFNA1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.