The authors analysed lesional skin cytokine changes (IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L, and TNF-α) before and after the treatments, observing a positive correlation between an mSWAT decrease and the levels of IL22, IL33, and TNF-α in the tumor tissue. This evidence concerns the gene IL22 and neoplasm.