First, we have demonstrated in models of atherosclerosis [58,72], multiple sclerosis (MS) [53,73], and COVID-19 [74] that plasma Reelin inactivation reduces inflammatory cell recruitment by decreasing the expression of leukocyte–endothelial adhesion proteins (E-selectin, ICAM-1, and VCAM-1). Here, RELN is linked to atherosclerosis.