SOX9 and digestive system neoplasm: Figure 2 summarizes the cellular reprogramming and tissue remodeling events associated with different types of DR development. Invasive DRs associated with cholestatic liver injury and fibrosis comprise reactive cholangiocytes, LPCs, and periductular SOX9+ hepatocytes (Figure 2B). In the case of invasive DRs associated with extensive hepatic necrosis, apart from reactive cholangiocytes, LPCs, and periportal SOX9+ hepatocytes, transdifferentiated mature hepatocytes are also involved in the formation DRs (Figure 2C).