However, TPIS downregulation could be functional in tumors, since TPIS activity could be responsible for the production of toxic levels of MGO deriving from glucose metabolism [106], while P2X7R-induced QCR1 decreased expression could be compatible with the known mitochondrial alterations reported in GBM, which compromise the energy supply through oxidative phosphorylation [107]. Here, SPAG1 is linked to glioblastoma.