ANXA2 and central nervous system cancer: Likewise, ANXA2, which has been isolated in EVs from glioma cell lines and patients, is an important mediator of EV-cell interactions able to promote tumor angiogenesis [78] and the circADAMTS6/ANXA2/NF-κB axis plays an important role in accelerating GBM growth in a hypoxic microenvironment [79].