In contrast with this, a later study by another group suggested that high expression of LRRK2 by using LRRK2 transgenic mice also promotes intestinal inflammation when using the same animal model, and they found that the LRRK2 kinase inhibitor attenuates colitis severity in both LRRK2 transgenic mice and WT controls [47]. The gene discussed is LRRK2; the disease is colitis.