Consistent with the latter study, Lin et al. used LRRK2 G2019S transgenic mice and found that LRRK2 G2019S promotes intestinal inflammation in a DSS-induced chronic colitis model by upregulating TLRs, NF-κB and pro-inflammatory cytokines, especially TNF-α [71]. The gene discussed is LRRK2; the disease is Chronic colitis.