It is noteworthy that while the approaches used to induce colitis between the Baekelandt V group and our group differ, our results using G2019S KI mice, along with the two previous studies using LRRK2 [47] or LRRK2 G2019S transgenic mice [71], support the notion that gain-of-kinase activities of LRRK2 promote intestinal inflammation. This evidence concerns the gene LRRK2 and colitis.