To address this limitation, we utilized LRRK2 G2019S KI mice and revealed that LRRK2 G2019S KI mice displayed notable weight loss, shortened colon length, increased spleen weight and heightened gut damage compared to WT littermates, suggesting that LRRK2 G2019S promotes colitis in the DSS-induced acute colitis model. This evidence concerns the gene LRRK2 and colitis.