After AOM administration and the first cycle of DSS treatment, we found a much stronger induction of the inflammatory genes of IL-1β, IL-6 and COX-2 in colon tissues of LRRK2 KI mice compared to those in WT controls on day 8 and day 15 after AOM/DSS treatment, but these genes were not primed by AOM alone three days after its administration (Figure 7B). Here, PTGS2 is linked to infectious otitis media.