Consistent with the enhanced expression of pro-inflammatory and pro-tumorigenic genes in the colon tissue of LRRK2 KI mice, immunofluorescent staining uncovered an increased number of Ki-67-positive cells in the colon epithelium of LRRK2 KI mice 15 days after AOM/DSS administration (Figure 7D), indicating elevated cell proliferation of IECs in the guts of LRRK2 KI mice during the early stages of AOM/DSS induction when compared with WT controls. The gene discussed is LRRK2; the disease is infectious otitis media.