The DGCR8 comprehension in thyroid disease is only in its infancy and it is expectable that the impact of DGCR8 in TC and its consequent miRNA expression dysregulation could direct further studies in order to elucidate what the contribution of this alteration is in the thyroid gland, as well described in Wilms’ tumors, and if it opens novel potential therapeutics opportunities for TC, e.g., using RNA-based miRNA inhibitors or supplements to modulate the cancer cells. The gene discussed is DGCR8; the disease is cancer.