Additionally, it has been shown that CAFs from colon cancer promote IL8/CXCR2-mediated monocyte adhesion and attraction through upregulation of VCAM-1 expression and IL-6 production, and subsequently promote polarization to an M2 phenotype by expression of CD163 and CD206 [26]. This evidence concerns the gene CXCL8 and malignant colon neoplasm.