To further investigate that the 67 kDa immunoreactive protein detected with anti-RPSA antibodies and historically associated with the 67LR may corresponds to 67EBP, we analyzed the expression of immunoreactive proteins associated with the 67 kDa RPSA-immunoreactive component and 67EBP in normal HIEC-6 cells and colorectal cancer cell lines Caco-2/15, SW480, SW620, HT29, and T84. The gene discussed is RPSA; the disease is colorectal cancer.