YAP1 and hepatocellular carcinoma: Interestingly, it has been shown that sirtuin 1 (SIRT1), a NAD+‐dependent protein deacetylase, deacetylates YAP2 in hepatocellular carcinoma (HCC) cells and SIRT1‐mediated YAP deacetylation increases the YAP2‐TEAD4 association, leading to YAP2‐TEAD4 transcriptional activation and upregulated cell growth in HCC cells.36