However, for the association of the plasma Aβ42/40–GFAP–p‐τ–NfL cascade with the development of dementia, we cannot rule out the possibility that our observation of plateaus in the associations between these plasma biomarkers and the risk of dementia does not accurately reflect the real‐life relations due to the relatively short term of follow‐up. The gene discussed is NEFL; the disease is dementia.