For GFAP, compared with participants with the lowest quartile, those with the highest quartile had a significantly higher mean value of age and frequencies of women, history of stroke, and history of cerebrocardiovascular disease, and significantly lower mean values of systolic blood pressure, eGFR, and BMI and frequencies of antihypertensive agent use, hypertension, diabetes, smoking habits, and alcohol intake. The gene discussed is GFAP; the disease is diabetes mellitus.