SLC2A1 and diabetes mellitus: 31), and subsequently uncovered a positive upregulation of MG-H1 and MG in synovial fluid of participants with OA and DM (Ref. 28). Pentosidine was significantly higher in both the bone and cartilage of OA with DM individuals compared with non-DM OA individuals (Ref. 36). In addition, following high-GLUT-1 expression in Li et al.'s study, significantly higher accumulation of AGEs in subjects with OA and DM was found (Ref. 23).