We found that antiplatelet/anticoagulant drugs had no effect on the survival of elderly patients with UGIB, and the independent risk factors affecting the survival of patients were CHF (HR 8.638, P < 0.001, 95.0% CI 3.211–8.638), cirrhosis (HR 4.443, P = 0.010, 95.0% CI 1.421–4.443), creatine kinase (HR 1.002, P < 0.001, 95.0% CI 1.001–1.002), and albumin (HR 0.916, P = 0.024, 95.0% CI 0.849–0.916). Here, ALB is linked to Cirrhosis.