IL22 and Eczematoid dermatitis: IL-22 exacerbates eczema through binding to IL-22R and activating a range of signaling pathways, including extracellular regulated protein kinases (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen activated protein kinases (p38MAPK), nuclear transcription factor-κB (NF-κB), and activator protein-1 (AP-1) (17–19).