Given that systemic immunity is also critical for tumor progression,20 we also found that LSS knockdown increased the percentage of monocytes (Figure 3F,G) and the number of PMN‐MDSC (Figure 3I), but did not affect M‐MDSC (Figure 3H) in the spleen, suggesting that PMN‐MDSCs are also involved in the anti‐tumor effect of LSS. This evidence concerns the gene LSS and neoplasm.