Methylated PRE of LTR5HS binds progesterone receptors (PRs) with higher affinity in T47D cells, and PRs would recruit OCT4 to the LTR5HS element, thus activating the expression of HERV-K, the Env protein of which promotes cancer development through the Ras-Raf-MEK-ERK pathway (Nguyen et al., 2019). Here, WNK3 is linked to cancer.