High expression of PRLH1 was found in p53-mutated hepatocellular carcinoma (HCC) samples and PRLH1 could promote the proliferation of p53-mutated HCC cells through binding to E3 ubiquitin ligase RNF169, thus supplanting 53BP1 at double-strand break sites and promoting the initiation of HR repair (Deng et al., 2019) (Figure 5). Here, RNF169 is linked to hepatocellular carcinoma.