An inactivating variant in GATM leads to Fanconi renotubular syndrome 1 (OMIM phenotype number 134600), an AD condition associated with decreased solute and water reabsorption in the PT with polydipsia, polyuria, phosphaturia, glycosuria, aminoaciduria, uricosuria, hypophosphatemic rickets, metabolic acidosis, progressive kidney insufficiency, and NC in 1 definitive case, and at least 1 case of AD Fanconi syndrome suspected to be secondary a variant in GATM, although genetic testing was not performed (Wen et al., 1989; Reichold et al., 2018; Seaby et al., 2023). Here, GATM is linked to Alzheimer disease.